⚠️ Disclaimer: These results are not wet lab-verified and are subject to testing, with no guarantees of high performance. Please contact RNAV8 Bio for further assistance: devan@rnav8bio.com
Design Parameters
Gene / Protein name
Anti-CD19 BBz CAR · 1428 nt · 475 aa
SP(22) · FMC63-VL(107) · G4S×3 · FMC63-VH(119)
CD8α-HTM(47) · 4-1BB(42) · CD3ζ(112)
Sequence input
DNA or RNA · ATG → stop codon
— nt
Target cell type(s)
Hepatocyte
Muscle
Dendritic cell
T cell
Neuron
Lung epi.
Lung cell
iPSC
HSC
HEK293
UTR strategy
5′ UTR
3′ UTR
Chemistry
Cap analog
CleanCap
ARCA
m7G
Nucleotide mod
m1Ψ
Ψ
5mC
Unmod
Poly-A tail
A100
A120
A150
Codon optimization engine
HIVE-CUT
Optimization
Optimization goal
Notes for agent
Agent log
Optimized sequences
QC Report
History
⬡
Configure parameters on the left
and click DESIGN mRNA to run.
◇
Run the agent first.
✓
Run the agent first.
📋
No previous designs yet.
Data sources & status
Science foundation
Built on peer-reviewed databases and validated codon usage tables curated by RNAV8 Bio's science team.
Codon frequency
curated
miRNA seed atlas
curated
UTR expression library
curated
RBP binding motifs
curated
Structure prediction
model
RNAV8 Bio in-house data
proprietary
Pipeline
6-tool agentic loop via Claude tool-use API:
validate_orf · optimize_codons
select_utrs · predict_structure
scan_mirna_rbp · synthesize_candidates